J. Cogn. Neurosci.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dalton, K. M.
Right arrow Articles by Davidson, R. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dalton, K. M.
Right arrow Articles by Davidson, R. J.
(Journal of Cognitive Neuroscience. 2005;17:969-980.)
© 2005 The MIT Press

Neural–Cardiac Coupling in Threat-Evoked Anxiety

Kim M. Dalton, Ned H. Kalin, Thomas M. Grist and Richard J. Davidson

University of Wisconsin

Reprint requests should be sent to Kim M. Dalton or Richard J. Davidson, W. M. Keck Laboratory for Functional Brain Imaging and Behavior at the Waisman Center, University of Wisconsin, 1500 Highland Avenue, Madison, WI 53706, or via e-mail: kmdalton{at}facstaff.wisc.edu or rjdavids{at}wisc.edu.

Anxiety is a debilitating symptom of many psychiatric disorders including generalized anxiety disorder, mood disorders, schizophrenia, and autism. Anxiety involves changes in both central and peripheral biology, yet extant functional imaging studies have focused exclusively on the brain. Here we show, using functional brain and cardiac imaging in sequential brain and cardiac magnetic resonance imaging (MRI) sessions in response to cues that predict either threat (a possible shock) or safety (no possibility of shock), that MR signal change in the amygdala and the prefrontal and insula cortices predicts cardiac contractility to the threat of shock. Participants with greater MR signal change in these regions show increased cardiac contractility to the threat versus safety condition, a measure of the sympathetic nervous system contribution to the myocardium. These findings demonstrate robust neural–cardiac coupling during induced anxiety and indicate that individuals with greater activation in brain regions identified with aversive emotion show larger magnitude cardiac contractility increases to threat.




This article has been cited by other articles:


Home page
 Cereb CortexHome page
A. Lerner, A. Bagic, T. Hanakawa, E. A. Boudreau, F. Pagan, Z. Mari, W. Bara-Jimenez, M. Aksu, S. Sato, D. L. Murphy, et al.
Involvement of Insula and Cingulate Cortices in Control and Suppression of Natural Urges
Cereb Cortex, May 9, 2008; (2008) bhn074v1.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. J. Gianaros, L. K. Sheu, K. A. Matthews, J. R. Jennings, S. B. Manuck, and A. R. Hariri
Individual Differences in Stressor-Evoked Blood Pressure Reactivity Vary with Activation, Volume, and Functional Connectivity of the Amygdala
J. Neurosci., January 23, 2008; 28(4): 990 - 999.
[Abstract] [Full Text] [PDF]

Home page
 J. Cogn. Neurosci.Home page
C. M. van Reekum, H. L. Urry, T. Johnstone, M. E. Thurow, C. J. Frye, C. A. Jackson, H. S. Schaefer, A. L. Alexander, and R. J. Davidson
Individual Differences in Amygdala and Ventromedial Prefrontal Cortex Activity are Associated with Evaluation Speed and Psychological Well-being.
J. Cogn. Neurosci., February 1, 2007; 19(2): 237 - 248.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
NEURAL COMPUTATION J COGNITIVE NEUROSCIENCE MIT PRESS JOURNALS
Copyright © 2005 by The MIT Press.