HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lenartowicz, A. Articles by McIntosh, A. R. Search for Related Content PubMed PubMed Citation Articles by Lenartowicz, A. Articles by McIntosh, A. R.

The Role of Anterior Cingulate Cortex in Working Memory is Shaped by Functional Connectivity

¹ Princeton University, ² University of Toronto

Reprint requests should be sent to A. R. McIntosh, Rotman Research Institute of Baycrest Centre, 3560 Bathurst Street, Toronto, Ontario, Canada M6A 2E1, or via e-mail: mcintosh{at}psych.utoronto.ca.

The anterior cingulate (AC) cortex seems to be similarly engaged by attentional and memory processes. We tested the hypothesis that this common activation is best explained by changes in the regions interacting (functionally connected) with AC. Subjects were tested on two variants of a 2-back working memory task: a standard version with strong attentional demands, and a cued version that more strongly promoted memory retrieval. AC activation, measured with functional MRI, was found in both tasks, although more sustained in the standard condition. The regions functionally connected to the AC, and the relation of these activity patterns to memory performance, were completely different across tasks. In the standard task, the pattern related to a speed–accuracy tradeoff, whereas the connectivity pattern unique to the cued task related only to better accuracy. By virtue of these changing patterns of functional connectivity, the contribution of AC to attention- and memory-driven performance was similarly changed.

This article has been cited by other articles:

				A. B. Protzner and A. R. McIntosh Modulation of Ventral Prefrontal Cortex Functional Connections Reflects the Interplay of Cognitive Processes and Stimulus Characteristics Cereb Cortex, September 11, 2008; (2008) bhn146v1. [Abstract] [Full Text] [PDF]

				P. Allen, A. Mechelli, K. E. Stephan, F. Day, J. Dalton, S. Williams, and P. K. McGuire Fronto-temporal Interactions during Overt Verbal Initiation and Suppression J. Cogn. Neurosci., September 1, 2008; 20(9): 1656 - 1669. [Abstract] [Full Text] [PDF]

				R. S. Marshall, J. J. Ferrera, A. Barnes, Xian Zhang, K. A. O'Brien, M. Chmayssani, J. Hirsch, and R. M. Lazar Brain Activity Associated With Stimulation Therapy of the Visual Borderzone in Hemianopic Stroke Patients Neurorehabil Neural Repair, April 1, 2008; 22(2): 136 - 144. [Abstract] [PDF]

				C.-S. Chan, J. M. Levenson, P. S. Mukhopadhyay, L. Zong, A. Bradley, J. D. Sweatt, and R. L. Davis {alpha}3-Integrins are required for hippocampal long-term potentiation and working memory Learn. Mem., September 6, 2007; 14(9): 606 - 615. [Abstract] [Full Text] [PDF]

				A. B. Protzner and A. R. McIntosh The Interplay of Stimulus Modality and Response Latency in Neural Network Organization for Simple Working Memory Tasks J. Neurosci., March 21, 2007; 27(12): 3187 - 3197. [Abstract] [Full Text] [PDF]

				J. W. Buckholtz, A. Meyer-Lindenberg, R. A. Honea, R. E. Straub, L. Pezawas, M. F. Egan, R. Vakkalanka, B. Kolachana, B. A. Verchinski, S. Sust, et al. Allelic Variation in RGS4 Impacts Functional and Structural Connectivity in the Human Brain J. Neurosci., February 14, 2007; 27(7): 1584 - 1593. [Abstract] [Full Text] [PDF]