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Cerebrocerebellar Circuits for the Perceptual Cancellation of Eye-movement-induced Retinal Image Motion

Hertie-Institut für Clinical Brain Research, Germany

Reprint requests should be sent to Peter Thier or Alex Lindner, Hertie-Institute for Clinical Brain Research, Department of Cognitive Neurology, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany, or via e-mail: thier{at}uni-tuebingen.dealindner{at}caltech.edu.

Despite smooth pursuit eye movements, we are unaware of resultant retinal image motion. This example of perceptual invariance is achieved by comparing retinal image slip with an internal reference signal predicting the sensory consequences of the eye movement. This prediction can be manipulated experimentally, allowing one to vary the amount of self-induced image motion for which the reference signal compensates and, accordingly, the resulting percept of motion. Here we were able to map regions in CRUS I within the lateral cerebellar hemispheres that exhibited a significant correlation between functional magnetic resonance imaging signal amplitudes and the amount of motion predicted by the reference signal. The fact that these cerebellar regions were found to be functionally coupled with the left parieto-insular cortex and the supplementary eye fields points to these cortical areas as the sites of interaction between predicted and experienced sensory events, ultimately giving rise to the perception of a stable world despite self-induced retinal motion.

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